A prospective comparison of HLA-epitope-matched and standard HLA-matched platelet transfusions in raising the platelet count increment in alloimmunised thrombocytopenic patients with aplastic anaemia or myelodysplastic syndrome. A crossover superiority trial.
Chief investigator: Professor Judith Marsh
Location/Institution: Kings College London
Funder: NHSBT Research and Development Committee
NHSBT Research Theme: Patient Blood Management
The HLA-Epitope trial was a double-blind crossover trial designed to compare the effect of HLA Epitope-matched (HEM) with standard HLA-matched (HSM) prophylactic platelet transfusions in raising the platelet count increment after transfusion in alloimmunised, thrombocytopenic patients with aplastic anaemia, myelodysplastic syndrome or acute myeloid leukaemia.
The trial tested whether a new way of matching platelets for transfusion was better in patients with blood disorders. The study compared a new way of selecting platelets for transfusion with the method currently in use. It aimed to provide the evidence to support a new method of matching donors and patients; making it easier to find well matched platelets and meet patient needs.
The study successfully met its recruitment target and the data is currently being analysed.