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PITHIA

Title
PITHIA: Pre-Implantation trial of Histopathology in renal Allografts
PITHIA: Pre-Implantation trial of Histopathology in renal Allografts
Study Type
PITHIA: Pre-Implantation trial of Histopathology in renal Allografts
Stepped-wedge cluster randomised trial
Chief Investigator(s)
PITHIA: Pre-Implantation trial of Histopathology in renal Allografts
Mr Gavin Pettigrew
Primary Sponsor
PITHIA: Pre-Implantation trial of Histopathology in renal Allografts
Cambridge University Hospitals
Funder
PITHIA: Pre-Implantation trial of Histopathology in renal Allografts
NIHR Research for Patient benefit
NHSBT Research Theme
PITHIA: Pre-Implantation trial of Histopathology in renal Allografts
Organ Donation and Transplantation
Summary
PITHIA: Pre-Implantation trial of Histopathology in renal Allografts
Does the introduction of a national, pre-implantation biopsy histopathology service increase numbers and improve outcomes of kidney transplants performed in the UK?
Study Hypothesis
PITHIA: Pre-Implantation trial of Histopathology in renal Allografts

Provision of a national, 24/7 pre-implantation biopsy service results - at reasonable cost - in the transplantation of a greater proportion of kidneys offered from ECD donors, and/or improves kidney transplant function at one year post-transplant.

Numbers of deceased donor kidney transplants performed annually in the UK are consequently significantly increased or improved in quality.

Study Design
PITHIA: Pre-Implantation trial of Histopathology in renal Allografts
An open, stepped-wedge cluster, randomised trial.
Study Contact
PITHIA: Pre-Implantation trial of Histopathology in renal Allografts

Emma Laing

Email: emma.laing@nhsbt.nhs.uk

Tel: 07471 147868

Publications
PITHIA: Pre-Implantation trial of Histopathology in renal Allografts
Ayorinde J, Summers DM, Pankhurst L, Laing E, Deary AJ, Hemming K, Wilson EC, Bardsley V, Neil DA, Pettigrew GJ. Pre Implantation Trial of Histopathology In renal Allografts (PITHIA): a stepped-wedge cluster randomised controlled trial protocol.
View publication on BMJ website