The InCiTe study is now complete.

Chief investigator: Dr Lise Estcourt
Primary sponsor: NHSBT

Study hypothesis

What factors (e.g. age, type of haematological disease, treatment, infection) are associated with an increased risk of developing an intra-cranial haemorrhage?

Study design

This study aims to collect anonymous data about haematological patients who have had an intracranial haemorrhage while undergoing intensive chemotherapy or a stem cell transplant.

This information is key to identifying means to improve treatment and quality of care.

This information will be collected through doctors and specialist nurses in hospitals throughout the UK. An information collection system will be developed for this study and will be based on similar systems in obstetrics (UKOSS) and paediatrics (BPSU). Assistance in the development of this system will be via BSBMT and advice from UKOSS. Once this system is in place it could also be used for future studies of rare disorders and complications within haematology that are difficult to study via any other method.

The design is a case-control study.


Estcourt LJ, Stanworth SJ, Collett D, et alIntracranial haemorrhage in thrombocytopenic haematology patients—a nested case–control study: the InCiTe study protocolBMJ Open 2014;4:e004199. doi: 10.1136/bmjopen-2013-004199.
View publication on BMJ website