Perfused Liver Utilisation Study

The PLUS study will evaluate if availability of normothermic machine perfusion (NMP) in extended criteria livers improves utilisation without compromising outcomes.

PLUS logo

Recruitment start date:

11 April 2022

The PLUS study will identify offers of donor livers less likely to be used and make the NMP machine available for storage and assessment.

We will compare the proportion resulting in successful transplants with a group of offers where NMP was not used to see if a pre-defined threshold for increased use is met.

We will also collect information about the overall cost of the new technology compared to the old, so that the NHS can decide whether NMP is good value for money.


National Institute of Health Research (NIHR)

NIHR logo

The University of Oxford

Oxford University logo

The PLUS study is funded by the National Institute for Health Research (NIHR) under its Intervention for Innovation challenge grant award (reference NIHR201003). The views expressed are those of the author(s) and not necessarily those of the NIHR or the Department of Health and Social Care.

The Sponsor of this study is the University of Oxford. The Sponsor has delegated overall management of this study to the Clinical Trials Unit at NHS Blood and Transplant.

Funding in-kind from OrganOx Ltd.