PLUS

Perfused Liver Utilisation Study

Chief Investigators: Professor Peter Friend and Mr Simon Knight
Primary sponsor: University of Oxford
Funder: NIHR Invention for Innovation Challenge Awards
NHSBT Research Theme: Organ Donation and Transplantation

Summary

Perfused Liver Utilisation Study. Utilisation of normothermic machine preservation in extended criteria livers - a national threshold-crossing study.

Study hypothesis

To assess whether normothermic machine preservation (NMP) can increase the availability of livers for transplantation without compromising the outcome.

Study design

Threshold-crossing design with prospectively-defined efficacy threshold comparing the impact of NMP versus standard static cold storage on functional utilisation of high-risk livers offered for transplant in the UK.

Study contact

Anthea Craven
Email: anthea.craven@nhsbt.nhs.uk