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REDDS

Title
Red blood cell transfusion thresholds and QoL in myelodysplastic syndromes. A pilot, feasibility study.
Red blood cell transfusion thresholds and QoL in myelodysplastic syndromes. A pilot, feasibility study.
Study Type
Red blood cell transfusion thresholds and QoL in myelodysplastic syndromes. A pilot, feasibility study.
Randomised controlled trial
Chief Investigator(s)
Red blood cell transfusion thresholds and QoL in myelodysplastic syndromes. A pilot, feasibility study.
Dr Simon Stanworth and Professor David Bowen
Primary Sponsor
Red blood cell transfusion thresholds and QoL in myelodysplastic syndromes. A pilot, feasibility study.
NHSBT
Funder
Red blood cell transfusion thresholds and QoL in myelodysplastic syndromes. A pilot, feasibility study.
NHSBT Trust Fund Grant
NHSBT Research Theme
Red blood cell transfusion thresholds and QoL in myelodysplastic syndromes. A pilot, feasibility study.
Patient Blood Management
Summary
Red blood cell transfusion thresholds and QoL in myelodysplastic syndromes. A pilot, feasibility study.

Red blood cell transfusion thresholds and Quality of Life in myelodysplastic syndromes (MDS). A pilot, feasibility study.

The ultimate goal of this feasibility trial is to inform the design for a large randomised controlled trial to compare a restrictive (transfuse to maintain haemoglobin concentration between 85 and 100g/L) with a liberal (transfuse to maintain haemoglobin concentration between 110-125g/L) red cell transfusion strategy for clinical outcomes.

Study Hypothesis
Red blood cell transfusion thresholds and QoL in myelodysplastic syndromes. A pilot, feasibility study.
A randomised controlled feasibility trial to evaluate protocol adherence between a restrictive (transfuse to maintain haemoglobin concentration between 85 and 100g/L) and a liberal (transfuse to maintain haemoglobin concentration between 110-125g/L) red cell transfusion strategy.
Study Contact
Red blood cell transfusion thresholds and QoL in myelodysplastic syndromes. A pilot, feasibility study.

Heather Smethurst

Email: heather.smethurst@nhsbt.nhs.uk

Tel: 07471 177896

Publication
Red blood cell transfusion thresholds and QoL in myelodysplastic syndromes. A pilot, feasibility study.

Simon J. Stanworth, Sally Killick, Zoe K. McQuilten, Marina Karakantza, Robert Weinkove, Heather Smethurst, Laura A. Pankhurst, Renate L. Hodge, Valerie Hopkins, Helen L. Thomas, Alison J. Deary, Jeannie Callum, Yulia Lin, Erica M. Wood, Rena Buckstein, David Bowen and on behalf of the REDDS Investigators. Red cell transfusion support in outpatients with myelodysplastic syndromes: a feasibility and exploratory randomised trial. Doi: 10.1111/bjh.16347