Red cell transfusion in Acute Myeloid Leukaemia

The REAL study is now complete.

Chief investigator: Dr Simon Stanworth
Primary sponsor: NHSBT
Funder: NHSBT Trust Fund Grant


A feasibility trial comparing restrictive versus liberal red cell transfusion strategies in adult patients with acute myeloid leukaemia receiving intensive chemotherapy.

Study hypothesis

It is feasible to achieve adherence when randomising patients to one of two haemoglobin thresholds and maintaining haemoglobin concentrations between either 71-80 g/L or 91-100 g/L.

Study design

A cross-over randomised controlled feasibility trial.

Study contact


Morton S, Sekhar M, Smethurst H, Mora A, Hodge RL, Hudson CL, Parsons J, Hopkins V, Stanworth SJ. Do liberal thresholds for red cell transfusion result in improved quality of life for patients undergoing intensive chemotherapy for acute myeloid leukemia? A randomized crossover feasibility study. Haematologica. 2022 Jun 1;107(6):1474-1478. doi: 10.3324/haematol.2021.279867. PMID: 35199504; PMCID: PMC9152957.
View publication on Haematologica website