The ATHENA study is now complete.

Chief investigator: Dr Lise Estcourt
Primary sponsor: NHSBT
Funder: NHSBT


Risk factors for haemorrhage in thrombocytopenic haematology patients. A pilot clinical investigation.

Study hypothesis

This pilot study will aim to examine a small number of patients in careful detail to document the key abnormalities in coagulation.

This is a preliminary study, and if a association is seen between coagulation abnormalities and bleeding this will guide the development of future studies.

Study design

The design is a prospective, observational cohort study which will follow the clinical course of patients admitted with a haematological malignancy that requires intensive chemotherapy or a stem cell transplant. Up to 50 patients will be recruited to the study.


Estcourt LJ, Stanworth SJ, Harrison P, Powter G, McClure M, Murphy M, Mumford AD. Prospective observational cohort study of the association between thromboelastometry, coagulation and platelet parameters and bleeding in patients with haematoogical malignancies – The ATHENA study. British Journal of Haematology. [E Pub 05 May 2014 doi: 10.1111/bjh.12928].