Improving Transplant Opportunities for Patients who are Sensitised

Chief investigator: Dr Sian Griffin
Primary sponsor: Cardiff and Vale University Health Board
Funder: Kidney Research UK


A study aimed at improving transplant opportunities for patients who are sensitised.

Study hypothesis

Treatment with a combination of B cell depletion and proteasome inhibition, together with antibody removal and steroids, will durably reduce calculated reaction frequency and facilitate renal transplantation in highly sensitised patients.

Study design

Three centre pilot study to inform a Phase 3, multicentre, open label trial.