EVNP DCD Kidney Trial

The EVNP study is now complete.

Chief investigator: Professor Michael Nicholson
Primary sponsor: University of Cambridge and Cambridge University Hospitals NHS Foundation Trust
Funder: Kidney Research UK


To determine if a short period of reconditioning using EVNP (Ex-vivo Normothermic Perfusion) improves initial graft function in DCD (donors after circulatory death) kidney transplantation.

Study hypothesis

Normothermic perfusion techniques offer an alternative form of organ preservation and resuscitation that has the potential to limit some of the effects of hypothermic preservation techniques. EVNP is a novel technique that may help to recondition ischaemically injured kidneys prior to transplantation. The aim of EVNP is to restore metabolism and function to the kidney prior to transplantation by circulating a warm oxygenated red cell based solution through the kidney.

Study design

A randomised controlled, open label trial with 1:1 allocation to either EVNP or cold storage (the current standard).

Study contact



Hosgood SA, Saeb-Parsy K, Wilson C, et al. Protocol of a randomised controlled, open-label trial of ex vivo normothermic perfusion versus static cold storage in donation after circulatory death renal transplantation. BMJ Open 2017;6:e012237. doi:10.1136/bmjopen-2016- 012237.
View publication on BMJ website

Hosgood, S.A., Callaghan, C.J., Wilson, C.H. et al. Normothermic machine perfusion versus static cold storage in donation after circulatory death kidney transplantation: a randomized controlled trial. Nat Med 29, 1511–1519 (2023). https://doi.org/10.1038/s41591-023-02376-7
View publication on Nature Medicine website