T regulatory cells and HSCT

Reference: TF054
Title: Study of the significance of T regulatory cells in the outcome of allogeneic Hematopoeitic Stem Cell Transplants (HSCT)
Chief investigator: Professor David Roberts

Summary

Bone marrow transplantation is often curative in leukaemia but it causes 20-30% mortality as the new cells fail to grow or attack the patient (graft versus host disease).

Immune cells called T regulatory cells are known to improve survival (Danby et al, 2015) and this study aims to confirm whether or not differences in the numbers of T regulatory cells improve outcomes following bone marrow transplantation.