Cell culture, product and assay development
The Protein Development and Production Unit (PDPU), focuses on the production and development of new and existing cell lines to supply monoclonal antibodies and recombinant proteins for research, diagnostic and therapeutic use.
Monoclonal antibodies for research use are marketed as IBGRL Research Products (IRP), while other reagents in our portfolio have been licensed for diagnostic use and bear the CE mark.
IRP are used by both academic and commercial customers worldwide, in every continent except Antarctica.
Services
PDPU can undertake the following services on either a collaborative or commercial basis (this list is not exhaustive):
- Production of antibodies and protein antigens from mouse, rat, human and insect cell lines
- Antibody engineering including isotype switching
- Antibody labelling e.g. FITC, RPE, AP
- Antibody fragmentation and fragment purification and labelling
- Protein purification, scale up and QC validation to customer specification including low endotoxin conditions
- CE marking of derived reagents
- Development of customer cell lines, including optimisation and stability studies and mycoplasma testing
- New hybridoma and recombinant cell line generation, optimisation and stability studies
- Phage display library screening (using antigen provided by customer)
- Provision of IBGRL cell lines under a license agreement
- Diagnostic assay development, validation & qualification (including CE marking)
- Diagnostic platform development, validation & qualification
Provision of IBGRL cell lines under a license agreement
If you are interested in any of our services please complete a Service Request Form - FRM5846 (Word 68KB)
If you would like to request a service that is not listed please contact us.
Please note: IBGRL does not currently undertake GMP manufacturing services but may support development of a GMP process. Where responses indicate a request for GMP manufacturing, IBGRL will pass details onto the Cellular & Molecular Therapies and/or Tissue & Eye Services functions of NHSBT.