Organ donation and transplantation

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Trials and studies in set up Trials and studies in recruitment and follow up Trials and studies in analysis Completed trials and studies

Trials and studies in set up

OrQA-UK

A novel clinical trial of an artificial intelligent enabled photograph assessment tool to improve organ utilisation in the United Kingdom.

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Trials and studies in recruitment and follow up

ASK

A trial of a patient and family outreach service to improve access to living-donor kidney transplantation.

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CLOTBUST-L

An open-label, multicentre, randomised controlled trial to evaluate the efficacy of ex situ fibrinolysis during normothermic perfusion in liver transplantation from donation after circulatory death donors

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DeFat

Defatting of donor transplant livers during normothermic perfusion – a randomised clinical trial.

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SIGNET

Statins for Improving Organ Outcome in Transplantation (SIGNET).

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LIMITS

The LIMITS trial will determine if relative limitation of fluid volume administered to children receiving kidney transplant is superior to usual liberal fluid volume administration.

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Trials and studies in analysis

COBALT

Cardiorespiratory Optimisation By AVF Ligation After Transplantation.

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PLUS

Utilisation of normothermic machine preservation in extended criteria livers – a national threshold-crossing study.

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Completed trials and studies

  • EVNP: To determine if a short period of reconditioning using EVNP (Ex-vivo Normothermic Perfusion) improves initial graft function in DCD (donors after circulatory death) kidney transplantation. Visit the EVNP trial page.
  • ITOPS: A study aimed at improving transplant opportunities for patients who are sensitised. Visit the ITOPS trial page.
  • PITHIA: Pre-Implantation trial of Histopathology in renal Allografts. Visit the PITHIA trial page. 
  • PLUTO: Plasma-Lyte Usage and assessment of kidney Transplant Outcomes in children. Visit the PLUTO trial page.
  • SONAR: A prospective observational cohort study to determine whether ultrasound surveillance can reliably predict arteriovenous fistulae (AVF) failure in patients with chronic kidney disease. Visit the SONAR trial page.

Generative AI has been used in the creation of the LIMITS trial logo found on this page. This generated content has been reviewed against the relevant NHS Blood and Transplant policies and approved by internal teams before use.


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