A randomised trial comparing two different platelet count thresholds for prophylactic platelet transfusions to preterm neonates.
Chief investigator: Dr Simon Stanworth and Dr Anna Curley
Location/Institution: Oxford University Hospitals NHS Foundation Trust
Funder: NHSBT Research and Development Committee
NHSBT Research Theme: Patient Blood Management
Platelets are the cells that help the blood to clot. Platelet transfusions are given to babies with low levels of platelets and signs of bleeding, but we do not know when best to give platelet transfusions to babies with low platelet levels and no signs of bleeding.
The aim of this study is to understand better when to give transfusions of platelets to babies with low platelet counts. For babies with low platelets and no evidence of bleeding, we would like to find out which platelet levels we should transfuse babies at. The team have therefore designed a new clinical study to compare outcomes for babies transfused at two different platelet levels.
Babies are randomised in to one of two groups:
- One group of babies will receive a platelet transfusion whenever their platelet count drops below 50.
- Another group will receive a platelet transfusion whenever their platelet count drops below 25.