Blood and transfusion

Trials and studies in set up

There are currently no trials and studies in set up under the blood and transfusion research theme.

Trials and studies in recruitment and follow up

Trials and studies in analysis

Completed trials and studies

• ADVENT: Automatic-DVT diagnostic software for the detection of deep vein thrombosis. Visit the ADVENT trial page.
• ATHENA: Risk factors for haemorrhage in thrombocytopenic haematology patients. A pilot clinical investigation. Visit the ATHENA trial page.
• CRYOSTAT-2: A multi-centre, randomised, controlled trial evaluating the effects of early high-dose cryoprecipitate in adult patients with major trauma haemorrhage requiring major haemorrhage protocol (MHP) activation. Visit the CRYOSTAT-2 trial page.
• DRIVE: A placebo-controlled double-blind, randomised feasibility trial to evaluate the feasibility of administering desmopressin (DDAVP) to Intensive Care patients prior to procedures or radiological interventions, for prophylaxis against bleeding. Visit the DRIVE trial page.
• E-FIT 1: A multi-centre, randomised, double blind, placebo controlled trial evaluating the effects of early administration of fibrinogen concentrate in adults with major traumatic haemorrhage. Visit the E-FIT 1 trial page.
• HLA-Epitope: A comparison of HLA epitope-matched (HEM) with standard HLA-matched prophylactic platelet transfusions in raising the platelet count increment in alloimmunised thrombocytopenic patients with aplastic anaemia, myelodysplastic syndrome or acute myeloid leukaemia. A double-blind randomised cross-over trial. Visit the HLA-Epitope trial page.
• InCiTe: What factors (e.g. age, type of haematological disease, treatment, infection) are associated with an increased risk of developing an intra-cranial haemorrhage? Visit the InCiTe trial page.
• ISOC-2: A prospective cross-sectional Observational Study of Haemostatic Testing in patients admitted to adult critical care with prolongation of prothrombin time without clinical bleeding. Visit the ISOC-2 trial page.
• PlaNeT-1: Platelets for Neonatal Transfusion – study 1. Visit the PlaNeT-1 trial page.
• PlaNeT-2: Platelets for Neonatal Transfusion – study 2. Visit the PlaNeT-2 trial page.
• PRISM: Trial of prion-filtered vs standard red cells in surgical and multi-transfused patients. Visit the PRISM trial page.
• PROMPT: A single centre randomised double blind parallel group trial comparing the outcomes of giving platelets from high versus low responder donors. Visit the PROMPT trial page.
• REAL: A feasibility trial comparing restrictive versus liberal red cell transfusion strategies in adult patients with acute myeloid leukaemia receiving intensive chemotherapy. Visit the REAL trial page.
• REDDS: Red blood cell transfusion thresholds and QoL in myelodysplastic syndromes. A pilot, feasibility study. Visit the REDDS trial page.
• RePAST: A feasibility study comparing restrictive versus liberal red cell transfusion strategies in children undergoing allogeneic haematopoietic stem cell transplant (HSCT). Visit the RePAST trial page.
• TAPS: Transfusion Alternatives Pre-operatively in Sickle Cell Disease. Visit the TAPS trial page.
• TOPPS: This study is a randomised controlled trial comparing prophylactic platelet use with no-prophylaxis in adult thrombocytopenic patients with haematological malignancies. Visit the TOPPS trial page.
• TREATT: Trial to evaluate tranexamic acid therapy in Thrombocytopenia. Visit the TREATT trial page.
• TRIGGER: A multicentre, feasibility, cluster randomised trial comparing restrictive versus liberal blood transfusion strategies in adult patients with acute upper gastrointestinal bleeding. Visit the TRIGGER trial page.