New Product Development

Tissue Services is committed to ensuring that its products and processes are state of the art, by rapidly incorporating new scientific developments and technologies into routine practices. The purpose of this is to make sure that the grafts that we supply are safe and of the highest possible quality. We achieve this by working closely with leading academic researchers, surgeons and other international tissue banking organisations.

New developments in tissue processing technologies and cell biology, particularly in the field of regenerative medicine (or 'Tissue Engineering'), have the potential to revolutionise the ways in which diseased or damaged tissue can be repaired or replaced. These technologies aim to create new types of graft which will overcome many of the drawbacks of traditional tissue replacement therapies. For example, by application of chemical and physical treatments, tissue allografts can be denuded of donor cells to create a clean, sterile and minimally immunogenic scaffold. These scaffolds can either be implanted directly into a patient, where they are repopulated with the patients cells much faster than traditional allografts, or combined with cells from allogeniec or autologous donors in vitro to make living tissue equivalents, with the biological and biomechanical properties similar to those of the patient's own tissue.

These protocols can be used to improve existing types of tissue graft, or prepare entirely new types of graft. For example, it has been established that bone allografts that are processed to remove blood and marrow contents are less immunogenic and are incorporated by recipients much more efficiently than unprocessed grafts. This process has been routinely applied to all shaped bone grafts supplied by the NHS Blood and Transplant for many years, and is continually being developed and refined to make it more efficient. It is also intended that the cleaned and marrow depleted matrices thus prepared will be used as scaffolds, to be reseeded ex vivo with a patients' own cells to create a living bone graft for re-implantation.

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