T regulatory cells and HSCT

Reference
TF054
TF054
Title
TF054
Study of the significance of T regulatory cells in the outcome of allogeneic Hematopoeitic Stem Cell Transplants (HSCT)
Chief Investigator
TF054
Professor David Roberts
Lay Summary
TF054
Bone marrow transplantation is often curative in leukaemia but it causes 20-30% mortality as the new cells fail to grow or attack the patient (graft versus host disease). Immune cells called T regulatory cells are known to improve survival (Danby et al, 2015) and this study aims to confirm whether or not differences in the numbers of T regulatory cells improve outcomes following bone marrow transplantation.