T regulatory cells and stem cell transplantation

Title
The role of T regulatory cells in haematopoietic stem cell transplantation
The role of T regulatory cells in haematopoietic stem cell transplantation
Chief Investigator
The role of T regulatory cells in haematopoietic stem cell transplantation
Professor David Roberts
Location/Institution
The role of T regulatory cells in haematopoietic stem cell transplantation
University of Oxford
Funder
The role of T regulatory cells in haematopoietic stem cell transplantation
NHSBT Research and Development Committee
Research Theme
The role of T regulatory cells in haematopoietic stem cell transplantation
Advanced Blood Components
Lay Summary
The role of T regulatory cells in haematopoietic stem cell transplantation

Haematopoietic stem cell transplantations (HSCTs) are used to successfully treat blood cancers (leukaemia). Unfortunately, up to 40% of patients who undergo HSCTs may die because the transferred cells attack the patient’s healthy tissues as well as the cancerous cells.

Prof Roberts is studying a subset of cells called T regulatory cells which are associated with improved survival in stem cell transplantation. Patients who receive above average levels of T regulatory cells have the best outcome. By increasing the proportion of these cells in the HSCTs used to treat leukaemia, it may be possible to improve patient survival.

The data collected from this work will therefore help us to know if selecting donor who have high T regulatory cells can improve patient outcome.