Improving Transplant Opportunities for Patients who are Sensitised
Chief investigator: Dr Sian Griffin
Primary sponsor: Cardiff and Vale University Health Board
Funder: Kidney Research UK
NHSBT Research Theme: Organ Donation and Transplantation
A study aimed at improving transplant opportunities for patients who are sensitised.
Treatment with a combination of B cell depletion and proteasome inhibition, together with antibody removal and steroids, will durably reduce calculated reaction frequency and facilitate renal transplantation in highly sensitised patients.
Three centre pilot study to inform a Phase 3, multicentre, open label trial.