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ITOPS

Title
ITOPS: Improving Transplant Opportunities for Patients who are Sensitised.
A pilot, open label, randomised, controlled phase III trial.
ITOPS: Improving Transplant Opportunities for Patients who are Sensitised.
A pilot, open label, randomised, controlled phase III trial.
Study Type
ITOPS: Improving Transplant Opportunities for Patients who are Sensitised.
A pilot, open label, randomised, controlled phase III trial.
Randomised controlled phase III trial
Chief Investigator(s)
ITOPS: Improving Transplant Opportunities for Patients who are Sensitised.
A pilot, open label, randomised, controlled phase III trial.
Dr Sian Griffin
Primary Sponsor
ITOPS: Improving Transplant Opportunities for Patients who are Sensitised.
A pilot, open label, randomised, controlled phase III trial.
Cardiff and Vale University Health Board
Sponsor
ITOPS: Improving Transplant Opportunities for Patients who are Sensitised.
A pilot, open label, randomised, controlled phase III trial.
Kidney Research UK
NHSBT Research Theme
ITOPS: Improving Transplant Opportunities for Patients who are Sensitised.
A pilot, open label, randomised, controlled phase III trial.
Organ Donation and Transplantation
Summary
ITOPS: Improving Transplant Opportunities for Patients who are Sensitised.
A pilot, open label, randomised, controlled phase III trial.
A study aimed at improving transplant opportunities for patients who are sensitised.
Study Hypothesis
ITOPS: Improving Transplant Opportunities for Patients who are Sensitised.
A pilot, open label, randomised, controlled phase III trial.
Treatment with a combination of B cell depletion and proteasome inhibition, together with antibody removal and steroids, will durably reduce calculated reaction frequency and facilitate renal transplantation in highly sensitised patients.
Study Design
ITOPS: Improving Transplant Opportunities for Patients who are Sensitised.
A pilot, open label, randomised, controlled phase III trial.
Two centre pilot study to inform a Phase 3, multicentre, open label trial.
Study Contact
ITOPS: Improving Transplant Opportunities for Patients who are Sensitised.
A pilot, open label, randomised, controlled phase III trial.

Samaher Sweity (Trial Manager)

Email: samaher.sweity@nhsbt.nhs.uk