EVNP DCD Kidney TrialEVNP DCD Kidney Trial
EVNP DCD Kidney TrialProfessor Michael Nicholson
EVNP DCD Kidney TrialUniversity of Cambridge and Cambridge University Hospitals NHS Foundation Trust
EVNP DCD Kidney TrialKidney Research UK
NHSBT research theme
EVNP DCD Kidney TrialOrgan Donation and Transplantation
EVNP DCD Kidney TrialTo determine if a short period of reconditioning using EVNP (Ex-vivo Normothermic Perfusion) improves initial graft function in DCD (donors after circulatory death) kidney transplantation.
EVNP DCD Kidney TrialNormothermic perfusion techniques offer an alternative form of organ preservation and resuscitation that has the potential to limit some of the effects of hypothermic preservation techniques. EVNP is a novel technique that may help to recondition ischaemically injured kidneys prior to transplantation. The aim of EVNP is to restore metabolism and function to the kidney prior to transplantation by circulating a warm oxygenated red cell based solution through the kidney.
EVNP DCD Kidney TrialA randomised controlled, open label trial with 1:1 allocation to either EVNP or cold storage (the current standard).
EVNP DCD Kidney Trial
EVNP DCD Kidney TrialHosgood SA, Saeb-Parsy K, Wilson C, et al. Protocol of a randomised controlled, open-label trial of ex vivo normothermic perfusion versus static cold storage in donation after circulatory death renal transplantation. BMJ Open 2017;6:e012237. doi:10.1136/bmjopen-2016- 012237