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DRIVE

Title
DRIVE: Desmopressin for procedures or Radiological InterVEntions.
A placebo-controlled double-blind, randomised feasibility trial of desmopressin (DDAVP) in critical illness prior to procedures.
DRIVE: Desmopressin for procedures or Radiological InterVEntions.
A placebo-controlled double-blind, randomised feasibility trial of desmopressin (DDAVP) in critical illness prior to procedures.
Study Type
DRIVE: Desmopressin for procedures or Radiological InterVEntions.
A placebo-controlled double-blind, randomised feasibility trial of desmopressin (DDAVP) in critical illness prior to procedures.
Randomised, double-blind controlled trial
Chief Investigator(s)
DRIVE: Desmopressin for procedures or Radiological InterVEntions.
A placebo-controlled double-blind, randomised feasibility trial of desmopressin (DDAVP) in critical illness prior to procedures.
Dr Mike Desborough
Primary Sponsor
DRIVE: Desmopressin for procedures or Radiological InterVEntions.
A placebo-controlled double-blind, randomised feasibility trial of desmopressin (DDAVP) in critical illness prior to procedures.
NHSBT
Funder
DRIVE: Desmopressin for procedures or Radiological InterVEntions.
A placebo-controlled double-blind, randomised feasibility trial of desmopressin (DDAVP) in critical illness prior to procedures.
NHSBT Trust Fund Grant
NHSBT Research Theme
DRIVE: Desmopressin for procedures or Radiological InterVEntions.
A placebo-controlled double-blind, randomised feasibility trial of desmopressin (DDAVP) in critical illness prior to procedures.
Patient Blood Management
Summary
DRIVE: Desmopressin for procedures or Radiological InterVEntions.
A placebo-controlled double-blind, randomised feasibility trial of desmopressin (DDAVP) in critical illness prior to procedures.
A randomised controlled trial to evaluate the feasibility of administering desmopressin to Intensive Care patients prior to procedures or radiological interventions, for prophylaxis against bleeding.
Study Hypothesis
DRIVE: Desmopressin for procedures or Radiological InterVEntions.
A placebo-controlled double-blind, randomised feasibility trial of desmopressin (DDAVP) in critical illness prior to procedures.

Approximately one third of patients in intensive care have a low platelet count and the majority undergo at least one invasive procedure during their time in there, putting them at an increased risk of bleeding.

This trial will assess the feasibility of administering desmopressin to thrombocytopenic patients in intensive care prior to a procedure or radiological intervention, for prophylaxis against bleeding.

This trial will also compare haemostatic/platelet function changes before and after administration of the IMP, between the two randomisation groups (desmopressin and placebo). This trial will help to inform the design of a larger randomised controlled efficacy trial of desmopressin vs placebo in intensive care.

Study Design
DRIVE: Desmopressin for procedures or Radiological InterVEntions.
A placebo-controlled double-blind, randomised feasibility trial of desmopressin (DDAVP) in critical illness prior to procedures.

This is a feasibility study and will be run as an interventional, randomised, double-blind, placebo-controlled trial. Patients will be randomised 1:1 using sealed opaque envelopes.

The study will be run and conducted within a single Trust in the UK (Oxford University Hospitals NHS Foundation Trust)

Study Contact
DRIVE: Desmopressin for procedures or Radiological InterVEntions.
A placebo-controlled double-blind, randomised feasibility trial of desmopressin (DDAVP) in critical illness prior to procedures.

Emma Laing

Email: emma.laing@nhsbt.nhs.uk

Tel: 07471 147868