PLEASE NOTE: This study is now complete.
In this study, we want to determine whether the activity/responsiveness of platelets given to stable patients with thrombocytopenia (low platelet numbers), affects patients’ platelet counts following transfusion.
We are also interested in investigating whether there is any change in the patient’s bleeding in the days after the platelet transfusion has been given. We will do this by randomising patients to receive a single platelet transfusion of either high or low responsiveness and monitoring the outcomes. In addition we will collect the outcome data from some enrolled patients who are given a non-study transfusion of platelets so that we can compare the results to the study transfusions.
We hypothesise that platelet units produced from donors who have platelets that are high responders to ADP (adenosine di-phosphate) and CRP-XL will function differently from those collected from donors with low responsive platelets. This difference in function in vivo will manifest as more rapid splenic clearance of platelets from high responders from the circulation following transfusion to patients.
This double-blind, randomised, controlled trial will test this hypothesis by comparing platelet count increments (CI) following transfusion of one platelet unit derived from high or low responders into stable thrombocytopenic patients.